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Results for "

Pyruvate Kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PDHK (15) Pyruvate Kinase (18) AIM2 (1) Apoptosis (2) Cannabinoid Receptor (1) Chloride Channel (1) Endogenous Metabolite (3) Fluorescent Dye (1) HIV (1) HSP (1) NF-κB (1) NO Synthase (1) Pyk2 (1) TNF Receptor (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (5) Inflammation/Immunology (6) Metabolic Disease (16) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Pyruvate Kinase PDHK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19702

PKR activator 3	Pyruvate Kinase	Metabolic Disease Inflammation/Immunology Cancer
PKR activator 3 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR activator 3 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia .

HY-12689

Mitapivat AG-348	Pyruvate Kinase	Metabolic Disease
Mitapivat (AG-348) is an orally active **pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR** genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency .

HY-114702

M77976 1 Publications Verification	PDHK	Metabolic Disease
M77976 is a specific ATP-competitive inhibitor of *PDK4 (pyruvate* dehydrogenase kinase isoforms 4), with an IC₅₀** of 648 μM. M77976 is potential for the research of obesity and diabetes .

HY-P2806

Pyruvate Kinase, Microorganism PK; FluoroKinase	Endogenous Metabolite	Metabolic Disease
Pyruvate Kinase, Microorganism (PK) is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP .

HY-138825

NCGC00188636	Pyk2	Metabolic Disease
NCGC00188636 is a novel covalent pyruvate kinase (PYK) inhibitor. NCGC00188636 blocks nucleotide binding to the active site of pyruvate kinase. NCGC00188636 can be used for the research of the metabolism of many organisms and cell types.

HY-139573A

(Rac)-Etavopivat (Rac)-FT-4202	Pyruvate Kinase	Cardiovascular Disease
(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies .

HY-146801

PDHK-IN-3	PDHK	Metabolic Disease Cancer
PDHK-IN-3 (compound 7) is a potent PDHK (pyruvate dehydrogenase kinase) inhibitor, with IC₅₀ values of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively .

HY-19330

DASA-58 10+ Cited Publications	Pyruvate Kinase	Metabolic Disease Cancer
DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer .

HY-161337

PKL-IN-1	Pyruvate Kinase	Metabolic Disease
PKL-IN-1 (Compound 12a) is a potent pyruvate kinase L (PKL) inhibitor with IC₅₀ values of 0.07 μM and 0.18 μM for PKL and PKR subtypes, respectively. PKL-IN-1 can inhibit 96.6% PKL activity at 10 μM concentration .

HY-136882

TM-1	PDHK	Cancer
TM-1 is a potent inhibitor of **pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC₅₀*s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate* dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation .

HY-157395

malonyl-NAC	Others	Cancer
malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH malonylation in cells and inhibits pyruvate kinase activity. In addition, malonyl-NAC limits the metabolism and proliferation of a highly glycolytic kidney cancer cell line harboring a tricarboxylic acid cycle mutation .

HY-119874

Alkannin	Pyruvate Kinase	Inflammation/Immunology Cancer
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent .

HY-134177

2,5-Anhydro-D-glucitol-1,6-diphosphate	Pyruvate Kinase	Metabolic Disease
2,5-Anhydro-D-glucitol-1,6-diphosphate is a limited stimulator of yeast Pyruvate Kinase. *2,5-Anhydro-D-glucitol-1,6-diphosphate is used as an analogue of the a-form, 2,5-anhydro-D-mannitol 1,6-bisphosphate, while is an excellent allosteric activator of Pyruvate* Kinase .**

HY-135884

Tebapivat AG-946; PKR activator 2	Pyruvate Kinase	Cardiovascular Disease
Tebapivat (PKR activator 2) is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385 .

HY-103617

PKM2-IN-1

10+ Cited Publications

Pyruvate Kinase Cancer

PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC₅₀ of 2.95 μM .

PKM2-IN-1 10+ Cited Publications	Pyruvate Kinase	Cancer
PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC₅₀ of 2.95 μM .

HY-153354

PKR activator 4	Pyruvate Kinase	Metabolic Disease
PKR activator 4 (example 7A) is a potent pyruvate kinase R (PKR) activator. PKR activator 4 has the potential for the research of blood disorders .

HY-135883

PKR activator 1

Pyruvate Kinase Cardiovascular Disease

PKR activator 1 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035865A1, compound E7-93 .

PKR activator 1	Pyruvate Kinase	Cardiovascular Disease
PKR activator 1 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035865A1, compound E7-93 .

HY-W005629

Leelamine	Cannabinoid Receptor PDHK	Cancer
Leelamine is a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine also inhibits pyruvate dehydrogenase kinases (PDKs). Leelamine exhibits anti-tumor activity .

HY-128578

KPLH1130	PDHK	Metabolic Disease Inflammation/Immunology
KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice .

HY-16082

AZD7545 1 Publications Verification	PDHK	Metabolic Disease
AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC₅₀s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively .

HY-139573

Etavopivat FT-4202	Pyruvate Kinase	Cardiovascular Disease
Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies .

HY-18657

TEPP-46 25+ Cited Publications ML-265	Pyruvate Kinase	Cancer
TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC₅₀ of 92 nM, showing little or no effect on PKM1, PKL and PKR .

HY-147368

PKM2 activator 2	Pyruvate Kinase	Cancer
PKM2 activator 2 (compound 28) is a pyruvate kinase M2 (PKM2) activitor with an AC₅₀ value of 66 nM. PKM2 activator 2 can restore normal glycolytic metabolism in cells .

HY-110124

ML202	Pyruvate Kinase	Cancer
ML202 is a highly specific allosteric activator of human pyruvate kinase M2 (hPK-M2), which can affect the cooperativity of phosphoenolpyruvate (PEP) binding, while adenosine diphosphate (ADP) binding almost no effect .

HY-12492

VER-246608 1 Publications Verification	PDHK	Cancer
VER-246608 is a potent and ATP-competitive inhibitor of **pyruvate dehydrogenase kinase (PDK) with IC₅₀s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4**, respectively.

HY-126585

SAICAR 1 Publications Verification	Endogenous Metabolite	Cancer
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC₅₀ of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions .

HY-157538

PDK4-IN-2	PDHK	Cardiovascular Disease
PDK4-IN-2 (compound 8) is a pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC₅₀ of 46 µM. PDK4-IN-2 improves ejection fraction of failing hearts by regulating bioenergetics via activation of the tricarboxylic acid cycle .

HY-D1876

ZY-2	Fluorescent Dye	Cancer
ZY-2 is a specific fluorescent probe for pyruvate kinase M2 (PKM2). ZY-2 can image in PKM2-positive cells in a time- and concentration-dependent manner. ZY-2 can be used for the detection of cancer cells .

HY-126585S

SAICAR-d1	Endogenous Metabolite	Metabolic Disease
SAICAR-d is the deuterium labeled SAICAR. SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].

HY-149814

PDK-IN-1	PDHK HSP	Cancer
PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC₅₀ values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass .

HY-148615

NPD10084	Pyruvate Kinase	Cancer
NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo .

HY-146552

PDHK-IN-4	PDHK	Metabolic Disease Cancer
PDHK-IN-4 (Compound 30) is a potent inhibitor of PDHK with IC₅₀s of 0.0051 and 0.0122 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-4 has the potential for the research of cancer diseases .

HY-146554

PDHK-IN-5	PDHK	Cancer
PDHK-IN-5 (Compound 19) is a potent inhibitor of PDHK with IC₅₀s of 0.006 and 0.0329 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-5 has the potential for the research of cancer diseases .

HY-157299

PDK-IN-3	PDHK	Cancer
PDK-IN-3 (compound 1) is a potent pan inhibitor of PDK with IC₅₀s of 109.3, 135.8, 458.7 nM and 8.67 μM against PDK 1-4, respectively. PDK-IN-3 also induces proliferation and apoptosis in A549 cells .

HY-135954A

PDK4-IN-1 hydrochloride 1 Publications Verification	PDHK Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC₅₀ value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 hydrochloride has antidiabetic, anticancer and anti-allergic activity .

HY-135954

PDK4-IN-1 1 Publications Verification	PDHK Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC₅₀ value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity .

HY-155850

CIAC001	Pyruvate Kinase	Neurological Disease
CIAC001 is a Pyruvate Kinase PKM2 inhibitor with anti-neuroinflammatory activity. CIAC001 inhibits LPS-induced proinflammatory nitric oxide (NO) production and protects immunologically active BV-2 cells (IC₅₀=2.5 μM). CIAC001 also has anti-neuroinflammation in mouse models and inhibits chronic morphine-induced addiction .

HY-B1142

Lipoamide 5 Publications Verification (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	NO Synthase	Others
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

HY-N0822

Shikonin Maximum Cited Publications 31 Publications Verification C.I. 75535; Isoarnebin 4	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2	Cancer
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-121744

PS10 2 Publications Verification	PDHK	Inflammation/Immunology
PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC₅₀ of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (K_d= 239 nM) than for Hsp90 (K_d= 47 μM) . PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy .PDK: pyruvate dehydrogenase kinase

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library	689 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 689 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

689 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 689 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L092

Glucose Metabolism Compound Library	1001 compounds
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer. MCE offers a unique collection of 1001 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

Glucose Metabolism Compound Library

1001 compounds

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer.

MCE offers a unique collection of 1001 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

ZY-2	Fluorescent Dyes/Probes
ZY-2 is a specific fluorescent probe for pyruvate kinase M2 (PKM2). ZY-2 can image in PKM2-positive cells in a time- and concentration-dependent manner. ZY-2 can be used for the detection of cancer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126585

SAICAR 1 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC₅₀ of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions .

HY-B1142

Lipoamide 5 Publications Verification (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	NO Synthase
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

HY-N0822

Shikonin Maximum Cited Publications 31 Publications Verification C.I. 75535; Isoarnebin 4	Quinones Structural Classification Classification of Application Fields Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Disease Research Fields Boraginaceae Cancer	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-119874

Alkannin	Quinones Structural Classification Monophenols Ohwia caudata (Thunberg) H. Ohashi Classification of Application Fields Source classification Phenols Plants Compositae Naphthalene Quinones Inflammation/Immunology Disease Research Fields	Pyruvate Kinase
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent .

Species:	Human (5) Rat (1) Mouse (4)
Tag:	His (9) Myc (1) GST (2)
Source:	HEK293 (1) P. pastoris (1) Sf9 insect cells (4) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P71210

	PKLR Protein, Human (HEK293, His) Pyruvate Kinase Isozymes R/L; Pyruvate Kinase 1; R-Type/L-Type Pyruvate Kinase; Red Cell/Liver Pyruvate Kinase; PKLR; PK1; PKL	Human	HEK293
	The PKLR protein is a key enzyme in cellular metabolism that acts as a pyruvate kinase, converting phosphoenolpyruvate to pyruvate. This process is an integral part of glycolysis, the fundamental pathway for cellular energy production. PKLR Protein, Human (HEK293, His) is the recombinant human-derived PKLR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PKLR Protein, Human (HEK293, His) is 574 a.a., with molecular weight of ~62.0 kDa.

HY-P700578

	PKLR Protein, Rat (P. pastoris, His) PKLR; Pyruvate Kinase, liver and RBC; PK1; PKL; PKR; RPK; PKRL; Pyruvate Kinase isozymes R/L; Pyruvate Kinase 1; OTTHUMP00000034069; Pyruvate Kinase type L; Pyruvate Kinase isozyme R/L; R-type/L-type Pyruvate Kinase; red cell/liver Pyruvate Kinase; Pyruvate Kinase, liver and blood cell; EC 2.7.1.40	Rat	P. pastoris
	PKLR Protein, a pyruvate kinase, plays a crucial role in glycolysis, converting phosphoenolpyruvate to pyruvate and generating ATP. As a key enzyme, PKLR mediates the final steps of glycolysis, contributing to energy production. Its catalytic activity influences pyruvate, a central metabolite with implications for cellular processes, including energy metabolism and the tricarboxylic acid (TCA) cycle. PKLR's significance in glycolytic flux underscores its essential role in cellular energy homeostasis, presenting potential for therapeutic interventions in metabolic pathways. PKLR Protein, Rat (P. pastoris, His) is the recombinant rat-derived PKLR protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of PKLR Protein, Rat (P. pastoris, His) is 574 a.a., with molecular weight of 64.2 kDa.

HY-P70599

	PKM2 Protein, Human (530a.a, His) Pyruvate Kinase PKM; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human (530a.a, His) is a recombinant PKM2 protein with a His-Flag. PKM2 Protein is one of the rate-limiting enzymes in glycolysis.

HY-P72053

	PKM2 Protein, Mouse (Baculovirus, His-Myc) Pkm; Pk3; Pkm2; PykmPyruvate Kinase PKM; EC 2.7.1.40; Pyruvate Kinase muscle isozyme	Mouse	Sf9 insect cells
	PKM2 protein catalyzes the final step of glycolysis, transferring a phosphoryl group from PEP to ADP to generate ATP. In the nucleus, transcriptional activation of PKM2 contributes to cancer progression, promoting cell proliferation and tumorigenesis. PKM2 is also involved in caspase-independent cell death in tumors. PKM2 Protein, Mouse (Baculovirus, His-Myc) is the recombinant mouse-derived PKM2 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of PKM2 Protein, Mouse (Baculovirus, His-Myc) is 531 a.a., with molecular weight of ~61.8 kDa.

HY-P74629

	PKM2 Protein, Mouse (sf9, His) Pyruvate Kinase M2; PKM2; CTHBP; OIP-3; THBP1	Mouse	Sf9 insect cells
	PKM2 protein catalyzes the final step of glycolysis, transferring a phosphoryl group from PEP to ADP to generate ATP. In the nucleus, transcriptional activation of PKM2 contributes to cancer progression, promoting cell proliferation and tumorigenesis. PKM2 is also involved in caspase-independent cell death in tumors. PKM2 Protein, Mouse (sf9, His) is the recombinant mouse-derived PKM2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of PKM2 Protein, Mouse (sf9, His) is 530 a.a., with molecular weight of ~59 kDa.

HY-P7803

	PKM2 Protein, Human (420 a.a, His) rHuPyruvate Kinase M2/PKM2, His; Pyruvate Kinase M2; PKM2; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human (420 a.a, His) is a multifunctional protein, is exclusively expressed in embryonic and adult dividing/tumor cells. PKM2 can catabolize glucose and involved in many nonglycolytic pathways.

HY-P701737

	PDK4 Protein, Human (GST) PDK4; [Pyruvate dehydrogenase (acetyl-transferring)] Kinase isozyme 4; mitochondrial; Pyruvate dehydrogenase Kinase isoform 4	Human	E. coli
	PDK4 Protein phosphorylates PDHA1 and PDHA2, inhibiting pyruvate dehydrogenase activity. This reduces glucose utilization, enhances fat metabolism, and helps maintain blood glucose levels during fasting. PDK4 also regulates fatty acid oxidation and biosynthesis, generates reactive oxygen species, protects epithelial cells, and regulates cell proliferation through metabolic regulation. PDK4 Protein, Human (GST) is the recombinant human-derived PDK4 protein, expressed by E. coli , with N-GST labeled tag. The total length of PDK4 Protein, Human (GST) is 411 a.a., .

HY-P71614

	PDK3 Protein, Mouse (His) Pdk3; Pyruvate dehydrogenase Kinase isoform 3	Mouse	E. coli
	PDK3 is a metabolic regulator that inhibits pyruvate dehydrogenase through PDHA1 phosphorylation to fine-tune glucose metabolism and affect aerobic respiration. Phosphorylation of PDHA2 adds another layer of control. PDK3 Protein, Mouse (His) is the recombinant mouse-derived PDK3 protein, expressed by E. coli , with N-His labeled tag. The total length of PDK3 Protein, Mouse (His) is 232 a.a., with molecular weight of ~30.3 kDa.

HY-P73718

	PDK1 Protein, Human (sf9, His) Pyruvate dehydrogenase Kinase isoform 1; PDK1; PDHK1	Human	Sf9 insect cells
	PDK1 protein is a key kinase that controls glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2. This molecular switch inhibits pyruvate dehydrogenase, fine-tunes metabolite flux and downregulates aerobic respiration. PDK1 Protein, Human (sf9, His) is the recombinant human-derived PDK1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of PDK1 Protein, Human (sf9, His) is 408 a.a., with molecular weight of ~45 kDa.

HY-P74639

	PDK4 Protein, Mouse (sf9, His-GST) Pyruvate dehydrogenase Kinase isoform 4; PDK4; PDHK4	Mouse	Sf9 insect cells
	PDK4 protein is a key kinase that regulates glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, modulates metabolite flux and inhibits aerobic respiration. PDK4 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived PDK4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PDK4 Protein, Mouse (sf9, His-GST) is 412 a.a., with molecular weight of ~65 kDa.

Cat. No.	Product Name	Chemical Structure

HY-126585S

SAICAR-d1
SAICAR-d is the deuterium labeled SAICAR. SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80870

PKM2 Antibody PKM; OIP3; PK2; PK3; PKM2; Pyruvate Kinase isozymes M1/M2; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate Kinase 2/3; Pyruvate Kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tu	WB	Human, Mouse, Rat, Monkey
PKM2 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 58 kDa, targeting to PKM2. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P83643

Phospho-PKM2(Tyr148)Antibody PKM2 (Phospho Tyr148); PKM2 (Phospho Y148); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PYKM; Pyruvate Kinase 1; Pyruvate Kinase 2/3; Pyruvate Kinase 3; Pyruvate Kinase isozyme R/L; Pyruvate Kinase isozymes M1/M2; Pyruvate Kinase liver and blood cell; Pyruvate Kinase liver and RBC; Pyruvate Kinase liver and RBC type; Pyruvate Kinase M2; Pyruvate Kinase muscle; Pyruvate Kinase muscle isozyme; Pyruvate Kinase type L; R type/L type Pyruvate Kinase; Red cell/liver Pyruvate Kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3; KPYM_HUMAN.	WB, IHC-P, IHC-F, ICC, IF, Flow-Cyt, ELISA	Human (predicted: Mouse, Rat, Pig, Cow, Rabbit, Sheep, GuineaPig)

HY-P83644

Phospho-PKM2(Tyr105)Antibody PKM2 (Phospho Tyr105); PKM2 (Phospho Y105); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PYKM; Pyruvate Kinase 1; Pyruvate Kinase 2/3; Pyruvate Kinase 3; Pyruvate Kinase isozyme R/L; Pyruvate Kinase isozymes M1/M2; Pyruvate Kinase liver and blood cell; Pyruvate Kinase liver and RBC; Pyruvate Kinase liver and RBC type; Pyruvate Kinase M2; Pyruvate Kinase muscle; Pyruvate Kinase muscle isozyme; Pyruvate Kinase type L; R type/L type Pyruvate Kinase; Red cell/liver Pyruvate Kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3.	IHC-P, IHC-F, IF, Flow-Cyt, ELISA	Human, Rat (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, GuineaPig)

HY-P81650

PDK2 Antibody (YA1395)

PDK2; PDHK2; [Pyruvate dehydrogenase [lipoamide]] Kinase isozyme 2; mitochondrial; Pyruvate dehydrogenase Kinase isoform 2
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

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